Kratom and Adderall combination is one potent combination! The two CNS stimulants act simultaneously to enhance mood, motor activities, cognition and help in achieving unachievable!

The combination of Adderall and Kratom means you are double dosing yourself with the strongest CNS stimulants available!

Yes, it has all the pros you could think of, but the mixture is deadly dangerous!

To know more about this mixture let’s have a look at the drugs individually and then their combination, along with pros and cons.

What is Adderall?

Adderall is the brand name of amphetamine, a drug used in treating attention deficit hyperactivity disorder, narcolepsy, and overeating.

Adderall is a combination of amphetamine and dextroamphetamine which acts as central nervous system stimulants.

Though it is a very useful drug, its therapeutic usefulness is limited due to psychological and physiological dependence similar to those with cocaine, and with chronic use, there are chances of developing tolerance to the euphoric and anorectic effects.

How does Adderall work?

The effects of amphetamine on the CNS are indirect. It acts by elevating the levels of catecholamines in the synaptic spaces. It achieved by releasing the intracellular stores of catecholamines. It also inhibits monoamine oxidase, the enzyme responsible in degenerating epinephrine and norepinephrine. Once this enzyme is inactivated, the neurotransmitter shows longer action.

Amphetamine also enhances the release of dopamine. It does so by stimulating the entire cerebrospinal axis, brainstem, and medulla. This leads to increased alertness, decreased fatigue, depressed appetite, and insomnia. At higher doses, psychosis and convulsions can ensue.

What is Kratom?

Composed mainly of the alkaloid mitragynine, Kratom acts as a painkiller, a stimulant, a mood booster and as an anxiolytic. The drug is also known for sedative action at higher doses. Previously used as an herbal medicine for chronic pain, this drug is more of a recreational substance now, and its abuse is very common.

The topic of its usefulness is quite controversial, and that is why it is banned in many parts of the world, however, we will be focusing on the therapeutic use of the drug for those who suffer from chronic pain and need to take a break from all sorts of opioids.

Kratom acts on the mu receptors of opiates to produce its effects.

At small doses it enables enhancement of productivity, brings about euphoria and causes a sense of well-being and calmness. At high doses, it causes sedation.

How does Adderall and Kratom combination work?

Adderall and Kratom work in synergy. The two drugs at low doses act as stimulants. Adderall has the effect of producing a sense of energy and enhances productivity while Kratom focuses more on calmness and brings about relaxation. Both drugs produce euphoria and a feeling of contentment.

At high doses, there is variation in the behavior of the two drugs. Kratom induces a sleep-like state and sedates while Adderall causes insomnia.

Reddit users explained in a thread that taking Kratom at night after taking Adderall during the day helps in making one sleep. Instead of taking Xanax that comes with dependence and tolerance, the best option is to take Kratom to induce sleep. However, other users were of the view that since Kratom is a CNS stimulant, it will potentiate the effects of Adderall

Kratom has helped many Adderall users to combat the Adderall crash and also to relieve the anxiety that is caused due to the regular use of Adderall. Drug forum users stated that Kratom and Adderall could act best together only if you find the right Kratom strain for yourself and there is a significant gap between dosing yourself with the two drugs. They explained that taking Adderall during the time to increase alertness and Kratom at night to induce sleep. However, the Kratom strain shouldn’t produce stimulation.

The strains that potentiate the effects of Adderall include Bali, Green, and White vein. On the other hand, red vein strain can be used for the comedown and induction of sleep.

Taking the two drugs together can induce euphoria and enhance focus. Kratom helps in maintaining a good mood and also avoids the depression caused as a side effect of Adderall. Kratom also helps manage pain that is due to skeletal muscle contraction, and it allows you to feel confident and productive without fearing a harsh comedown.

Adderall side effects

Dextroamphetamine and amphetamine may cause side effects, including:

  • Nervousness and Restlessness
  • Changes in sex drive or ability
  • Difficulty falling asleep or staying asleep
  • Uncontrollable shaking of a part of the body i.e. tremors
  • Headache
  • Dry mouth
  • Stomach pain
  • Nausea and vomiting
  • Diarrhea/ Constipation
  • Loss of appetite causing Weight loss
  • Fast or pounding heartbeat i.e. palpitations
  • Shortness of breath
  • Chest pain
  • Weakness or numbness of an arm or leg
  • Seizures
  • Mania (frenzied or abnormally excited mood)
  • Aggressive or hostile behavior
  • Changes in vision or blurred vision
  • Fever
  • Difficulty breathing or swallowing

Contraindications of Adderall

Adderall is contraindicated in the following cases.

  • Anxiety or agitation
  • Glaucoma
  • Family history of Tourette Syndrome or tics
  • Congenital Heart defects
  • Heart rhythm disorders, coronary heart diseases, history of myocardial infarction
  • Hypertension
  • Seizure disorder especially epilepsy
  • Mental illness like schizophrenia, mania
  • Peripheral vascular disease
  • Patients on MAOI’s inhibitors

Adderall and Kratom mixture precautions

  • Before taking the two drugs, you should be aware of your mental and physical status.
  • Don’t take Adderall if you have taken MAO inhibitor in the last two weeks.
  • Monitor the usage of Kratom and Adderall as the combination has a high risk for addiction or abuse.
  • Avoid snorting of Adderall as it can cause necrosis of the nasal septum along with severe respiratory irregularities.
  • Monitor the amount of alcohol that you drink while taking this combination.


The mixture of Adderall and Kratom is highly dangerous and should be avoided. Both drugs can cause severe dependence and are subject to tolerance. A person who is dependent on Adderall for carrying out day to day activities will take extreme measures to get hold of the drug even if that puts their well-being at risk.

If you take the combination of the two drugs, ensure that you take small doses and taper down the dose in case you want to quit the usage of Adderall.

If you stop taking Adderall all of a sudden you can face ‘Adderall crash,’ leaving you to feel sluggish, disoriented and disconnected. Also, you will have temporary symptoms of withdrawal.



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