When you are taking a medicine or some drug to elicit a response, it is important that you consider the appropriate doses, but more importantly, you should be aware of the methodology of taking the drug.
Taking drugs IV can cause quick and severe effects on heart and brain provided the drug crosses the blood-brain barrier. Taking drugs orally might not show the desired response, may be due to extensive first pass metabolism or interaction with the gastric juice, etc. before absorption.
This article will describe how to take Akuamma seeds, and it will also highlight the correct dosage with their respective effects.
ince the drug is primarily used as an analgesic, a standard dose can’t be mapped out because everyone isn’t suffering from the same kind of pain and everyone doesn’t have the same pain threshold. However, for the convenience of readers, reviews from different drug forums, including Reddit have been added into the article to give you a better insight into the experiences of other people and how you can relate them to yours.
How to take Akuamma Seeds?
You think you have tasted bitter by tasting Kratom? You are mistaken. Akuamma seeds are way bitter than Kratom.
Most people prefer to take Akuamma capsules as the bitter flavor is almost unbearable. Those who take it in the form of powder, add a sweetener or make it with tea.
Some users take Goji berry along with it to reduce the bitterness. You can purchase the Akuamma in the form of raw seeds, ground seed powder as well as capsules.
You can use an excellent coffee grinder to crush the seeds and then measure out the correct dose for yourself.
Never use a teaspoon as a scale to your dose. Always weigh the amount of powder that you will be taking. Use an accurate digital scale and then find the best capsule size for yourself. You can have vegan capsules too if you are allergic to the other ones.
Fill the capsules according to the dose that you ingest. This way you can have a stock of pills readily available to you.
Some users prefer the toss and wash method while others even chew the seeds, but it has been reported that eating the seeds can cause severe nausea and vomiting.
To avoid this, you can toss the required dose in a piece of the toilet or some rolling paper, twist it up and cut off the excess paper. Then swallow it.
Avoid drinking too much water after it because if you burp you will get the bitter taste all over again in your mouth.
How to prepare purified alkaloids from Akuamma seeds?
When using Akuamma seeds as an antiprotozoal drug, you can follow this method to take medicine. This process ensures that you get the purified form of the alkaloids. It comprises the following steps.
- Pulverising picralima nitida plant
- Use a solvent to extract the material. Dry it and then re-extract the dried material with a different solution.
- Extract a fresh sample of Akuamma with boiling water.
- Filter and concentrate the boiling water solvent extracts under reduced pressure.
- Concentrate the dried extract now to obtain the gum. Re-extract the Akuamma gum with an aqueous acidic HCl solution.
- Next, filter the acidic extract and make it alkaline to a pH of about 9 using NaOH solution.
- Extract the alkaline solution using dichloromethane, concentrate it and then dry it under reduced pressure to obtain an alkaloid fraction.
- Next, separate the alkaloid fraction using liquid chromatography-mass spectrometry to obtain purified alkaloids that can be employed in the treatment of various diseases.
What is the correct dosage of Akuamma seeds and how long does the effect last?
Average reported dosage by many users is around 250mg-500mg. This is almost equal to 1-2 seeds. If measured by spoon, this equal to 2/3rd of a teaspoon.
The extract usage is considerably less overall. Users state that an ounce powder usually lasts 20-30 days, but this totally depends on the usage of the individual.
To kill severe pain, people go for a dose as high as 2-4 grams, and according to some users, they experience analgesic effect at a high dose of 6 grams.
However, if you are new to this drug, it is recommended that you start with a little dose and then work your way up slowly to identify the proper dosage for yourself.
Users on Reddit reported that effects last for 3-4 hours maximum.
At what doses will I experience side effects?
Side effects start appearing with continuous use and high doses. Though Akuamma seeds have been accepted as a safe pain killing regimen, however, it must be mentioned that it is a sedative and high doses exceeding 6-8 grams can cause the depression of the respiratory center in the medulla resulting in a coma which can even prove fatal.
At a dose of 2 grams and higher, you will most probably experience headaches.
What is the best option for me?
Akuamma Seeds: Ground the whole seeds and use the toss and wash method. One seed is usually equal to 2/3rd of a spoon. Though it isn’t a pleasant way to ingest seeds, this approach is the most efficient and provides fast relief from pain and gives a sense of well-being.
Akuamma Seed Capsules: This is taking the Akuamma seed powder. One capsule is equivalent to 1 seed, and around three tablets provide the best analgesic effect. If you need a quicker relief, you can make a hole in the capsule or open it to toss and wash.
Akuamma Seed Tincture: For faster and fuller relief you can take few droppers full. It doesn’t have long lasting effects, but it gives the fastest way to pain relief.