Mitragynine is the most potential phytochemical of the plant Kratom. It majorly distributed in leaves of the plant which makes them the most powerful part to be used. Many of us don’t exactly know what an alkaloid is, what is mitragynine and how does it work.

Historically famous for hundreds of years, mitragynine is not thoroughly studied for its benefits up till now. To make the experience of Kratom usage more powerful, it is essential to sneak peek into the inside story i.e. what makes it so efficient.

This article will explain the working of mitragynine in a simple manner to be understood by the viewers.

What is Mitragynine?

Mitragynine is an indole-based alkaloid extracted from the plant Kratom, botanically known as Mitragyna speciosa. It is the major stimulant of the plant and exhibits antinociceptive and opiate-like effects which work through opiate receptors.

It is a natural analgesic and binds to the receptors responsible for the feeling of pain and control the body’s perspective towards it Mitragynine has the highest attraction for Mu- opioid receptor to which it binds and start working to control pain.

Mitragynine is traded commercially to be a part of semi-synthetic analgesic medicines.

Chemical properties of Mitragynine

Mitragynine chemically termed as C23H30N2O4. By area, it covers approximately 0.5-0.7% of the Kratom leaf, depending on the leaf size. It doesn’t appear as a “highly distributed” alkaloid but is the most prevailing among other 40+ alkaloids.

Its molecular weight is 398.50 g/mol. As being insoluble in water, it is used in organic solvents to make the solution. It was first isolated in 1921 and its detailed chemical structure was elaborated in 1964.

Other names given to mitragynine are (E)-16,17-didehydro-9,17-dimethoxy-17,18-seco-20α-yohimban-16-carboxylic acid methyl ester, 9 methoxy corynanthidine, and SK&F 12711.

Effects of Mitragynine on the human body

Mitragynine is called a natural relaxant and analgesic. It is responsible for pain management even for chronic diseases of joints and muscles. Other benefits include the following.

  • Reduces stress and anxiety
  • Concentration building
  • Improved focus
  • Memory building
  • Cognitive support
  • Cures insomnia
  • Aids in sleeping disorders
  • Energizing the body
  • Boosting immunity
  • Stamina building
  • Emotional support and mood enhancement

It is also associated with euphoric experiences. The quantity of how much you take mitragynine and what you take it for decides what would it reward you with. Many scientists believe that these properties don’t work for mitragynine only, but a synergetic combination of mitragynine with other alkaloids induces these effects which further studied in research labs.

How much dosage initiates its effects?

Dosage is an important consideration for using any medicinal extract. The lower dosage of Kratom induces fewer results, and high quantity initiates sedative and euphoric effects. If mitragynine is employed in Kratom form; the dosage may depend upon the strain type since some of the Kratom strains are highly reactive even in minor quantity.

How to use mitragynine?

Mitragynine is a natural part of Kratom so it can be obtained directly from using Kratom. Some users require pure mitragynine to be used for which it is extracted from the Kratom leaves scientifically. Different methods used for various concentration of mitragynine e.g. 8% mitragynine. The pure mitragynine powder is also traded commercially and bought by many of the users or oral intake.

Are the effects long lasting?

Kratom being called as a natural medicine has been part of traditional medicinal products for long. Since it’s an herbal product, the extracts of Kratom and pure mitragynine are considered beneficial for the longer run.

Unlike synthetic chemicals, they have a longer span of results which make them the “safe choice” for long term use by any person.

Toxicity and side effects of mitragynine

Herbal products are documented to be gentle for health and reduced risks. Although mitragynine is a safe phytochemical for the health some users might feel a mild side effect in initial use which goes away on its own. These side effects include following.

  • Digestive interference
  • Nausea
  • Dry mouth
  • dizziness
  • Irregular sleep cycles

There are no adverse side effects reported.

The bottom line

Mitragynine is the most active alkaloid in Mitragyna speciosa which is commonly called Kratom. Kratom is a natural healer who provides multiple benefits to the body.

Among all its alkaloids, the most reactive one is mitragynine which has the affinity for the opioid receptors thus controlling pain. For its advantages to be thoroughly enjoyed, a perfect dosage required which would not be the same for everyone.

Special precautions regarding dosage are recommended. However, there are no side effects reported.



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