Kratom and Hydrocodone are two nervous system stimulants which are used vastly across the globe.

Both these components being power boosters work for a similar reason which is to recreate alertness and focus that ultimate results into the upraised cognitive approach.

Since Kratom is a natural stimulator and Hydrocodone is a synthetic based chemical used majorly in medicines, both have different sources but work for one same function.

The combination of both gives an idea of a super mixture which has double reactions and benefits.

To understand this combination in detail, let’s figure out what makes it unique.

What is Kratom?

Kratom called as a magical plant is not an alien to most of the people. Being native to Southeast Asia, Kratom is botanically called Mitragyna speciosa.

It is a tropical deciduous tree which has been part of traditional medicine for long. It has been widely discussed over multiple blogs and various talks.

How does Kratom work?

Kratom is researched for its enhanced properties. Meanwhile, its new usages have been introduced to attain maximum benefits out of it.

It relieves pain, boosts immunity, provides energy, releases stress, ends anxiety and helps to cure insomnia. For such extensive properties, it is considered a medicinal plant as well.

Is it illegal?

Not. Initially, due to its sedative properties, it was considered as opium. But the researchers proved that it is more of a medicinal plant. It was long banned in Thailand as it was a threat to the national economy.

What is Hydrocodone?

Hydrocodone is a semi-synthetic opioid extracted from plant sources. It is used to treat chronic pains, and for this reason, it is a part of major chemically modified analgesic drugs.

Its action begins in 20-30 minutes and lasts for up to 8 hours. After the effects ended, another dosage is recommended.

How does Hydrocodone work?

Hydrocodone modifies the pain signaling by controlling the central nervous system. The human body has many opioid receptors which signal for the feeling of pain. From mild to chronic illnesses, these receptors work for their sensation.

Hydrocodone doesn’t block the source of pain but it works on the receptor setting and block the signaling, the result is reduced and finally no sensation of pain.

Similar effects of Kratom and Hydrocodone

The majority of effects which are shared by Kratom and Hydrocodone are same. The chemical composition is very similar, and both used for therapeutic purpose. Some of the major common benefits are following.

  • Natural Analgesic
  • Energy Provider
  • Immunity Booster
  • Behavioral Effect
  • Cardiovascular Support

Limitations on the use of Hydrocodone

Hydrocodone is not an entirely natural formula, it is half natural and half synthetic. Some patients might need care while taking it. Some mild side effects of Hydrocodone include the following.

  • Dysphoria
  • Digestive problem
  • Laziness
  • Fatigue
  • Nausea
  • Itchiness
  • Drowsiness

These side effects are mild and overridden on their own. Rarely the prolong if the user has a severe sensitivity to it. It is not recommended to underage children and sensitive users.

How to potentiate Kratom with Hydrocodone?

Kratom is often added with Hydrocodone to make the effect more durable and long-lasting. The potentiating can be done in any step of the extract collection, formulation or use.

If you are suffering from a medical condition e.g. a migraine, a potentiated Kratom will not only reduce pain but also remove the stress of that situation. It will take less than half an hour to provide you the results.

Kratom with Hydrocodone potentiated combination slow down the metabolism and inhibit the enzyme cytochrome P450. It regulates the breakdown of Kratom molecules which results in a prolonged effect.

How to make a perfect combination of Kratom and Hydrocodone?

Since both Kratom and Hydrocodone have the similar mode of action so yes they can be combined perfectly to make the effects more potent. Either they can be mixed with supplements as Kratom is available in powder form too.

The Hydrocodone is available in many forms including tablet or powder. Both these powders can be mixed in an appropriate ratio which relies heavily on the health status of the user. This mixed powder can be taken orally or infused in foods.

The amount of Kratom to be taken can be between 1-10 grams and above 10 grams for extreme medical conditions. For general usage, 1-3 grams is prescribed.

Hydrocodone can be taken up to 10 mg after every 12 hours, but this ratio majorly depends on a personal choice and health status. For the average, more Kratom and less Hydrocodone is acceptable, and no high dosage is suggested. It should be noticed to use the A prolonged usage may induce resistance, and only the significant quantities would work.

User reviews

A discussion from Drug forum suggests this to be a good idea to use both together. Another focus on the same dashboard told where a user used 15 mg Hydrocodone and was euphoric, but this may not work for all.

Whereas, for some users even a minor quantity works well, like a discussion thread on Reddit explains a user to mix 10 mg Hydrocodone in 650 mg Kratom.

Conclusively, it can be said that it is an effective combination, only the perfect dosage as per your body requirement to be set.


The combination of Kratom and Hydrocodone is very reactive yet very effective. Though there is no systematic study on the use of combined mixture, many users on online forums have used it.

Although it works very well, a mismanaged dosage might lead to serious side effects because both Kratom and Hydrocodone are very potential stimulants.

For the usage, the dosage should be highly précised and calculated. Overall, it is an effective combination only when used in the right amount.



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