People experiment with different things these days. New recipes are fun to prepare and fun to use. Same is the case with Kratom. Kratom users experiment with various drugs, supplements, and potentiators to enhance their Kratom experience.

Added potentiation that comes with the supplements helps them in achieving exaggerated effects. Nowadays Kratom users are taking Gabapentin with Kratom.

Are you curious about the combination of Gabapentin and Kratom? Do the substances interact with each other? How will you feel after consuming Gabapentin and Kratom together? To know these answers, let’s have a look at the article below.

What is Gabapentin?

gabapentinGabapentin, in other words, Neurontin is a drug that is generally taken by many for relieving the symptoms of withdrawal of opiate.

Though it is being tested for its efficacy as a treatment regimen of opiate discontinuation syndrome and as a pain killer in different morbid states, it is highly used by many.

Its role in analgesia in the case of post-herpetic neuralgia, neuropathic pain and other forms of chronic pain is significant. With the recounts of patients, it can be concluded that gabapentin is one amazing drug if used appropriately but definitely we need FDA’s approval for that.

How does Gabapentin work?

Gabapentin primarily acts on the central nervous system by blocking the voltage gated Calcium ion channels. These Ca+2 channels are blocked at the α2δ subunits. It has more affinity for α2δ subunit as compared to the α2δ2 subunit of the Ca+2 Ion channels.

These channels are responsible for the regulation of Ca+2 influxes when the neuronal membrane is depolarized.

When this regulatory mechanism is impaired due to any reason, certain motor and coordination abnormalities arise; the list also includes disorders like ataxia, epilepsy, migraine and neuropathic pain.

Also, it increases the synthesis of GABA neurotransmitter. In addition to this, it also acts on the NMDA receptors, protein Kinase C and GABAB receptors.

Enhancement of GABA alleviates the opiate withdrawal symptoms while deficiency of GABA results in anxiety and stress.

Increased levels of GABA also help in relieving muscle aches, convulsions, fits, pain, anxiety, etc.

How does Kratom work?

Kratom acts as a stimulant, painkiller, a mood booster and as an anxiolytic as it is composed mainly of the alkaloid mitragynine.

It acts as a sedative when a larger dose is consumed.

Kratom acts on the mu, delta and kappa receptors of opiates to produce its effects. Previously, it was as an herbal medicine for chronic pain, but now this drug is more of a recreational substance. Kratom abuse is very common these days.

The topic of its usefulness is quite questionable, and that is why it is forbidden in many parts of the world. However, we will be focusing on the therapeutic use of the drug in combination with Gabapentin for those who suffer from chronic pain and need to take a break from all sorts of opioids.

At low doses, it enables enhancement of productivity, brings about euphoria and causes a sense of well-being and calmness.

At high doses, it causes sedation and relaxes one, voiding him of all worries and tension.

How does Gabapentin potentiate Kratom?

Basically, from the information provided above, you must have had an idea that the mechanism of action of Gabapentin and Kratom are entirely different, yet somehow, they manage to produce the same effects.

Both Gabapentin and Kratom help in alleviating the withdrawal symptoms. Both of them work by providing analgesia.

Both drugs act as anxiolytics, relieving one from stress, worries, anxiety and depression.

They help in elevation of mood. So, it can be rightly said that if Gabapentin is taken with Kratom, it will potentiate the effects of Kratom.

The mechanism is totally unknown, but the experiences of users make us conclude that yes Gabapentin act as a potentiator of Kratom.

Do Gabapentin and Kratom interact?

The two substances if taken in monitored dose will never cause adverse interaction as stated by many users on various drug forums. However, increased dose of Gabapentin can enhance the effects of Kratom, making one too high or too sedated.

Many users claim that a dose of 300mg Gabapentin is more than enough to potentiate Kratom. Dosage greater than this can cause increased tolerance levels both to Gabapentin and Kratom. However, it is considered safe and synergistic to take Gabapentin and Kratom together.

Thus, it is recommended that if you wish to consume Gabapentin with Kratom, you should carefully choose the dosage. Larger doses of Gabapentin can make you feel lethargic and tired. Find a dosage that works best for you.

Avoid using this combination for recreational purposes. Only take it for Opiate withdrawal symptoms and chronic pain that may be due to cancer, neuralgia, trauma, surgery, osteoarthritis, rheumatoid arthritis, etc.



  1. Great article regarding Gabapentin and Kratom. I am a huge supporter of Kratom and my research is minimal, but when you listen to the natives talk about this I feel they know best. Anyway great article.

  2. I’m fixing to take a dose of green thai kraton with about 10 or 11 600mlg. Gabs…hope for the best. Just taking a teaspoon of the kratom I usually do 5 grams or over.

    • How irresponsible can you be? You are telling people you are about to take 6,000 mg of gabapentin. And Kratom on top of that.

  3. I have leukemia, psoriatic arthritis and degenerate disk disease. I take a 300 mg gab along with half a teaspoon of green maeng da Keaton 3 times a day. It doesn’t take the pain away but it definitely makes it much more tolerable.

  4. Omg, I’ve been on Gabapetin for yrs, 600mlg every 8hrs. I couldn’t imagine 10 of them with the kratom at once! Im takin 2mg of kratom every 4hrs.. I just started so im not taking anymore until I see how it works out with my meds, it seems to be working better then yesterday!

  5. I’m about to do this for my herniated disk/blown disk. I took 2 gabapentin though, will I build a tolerance if I just take 1 Kratom?


Please enter your comment!
Please enter your name here